The study is the first ever placebo-controlled pharmacogenetic drug trial for ADHD in children of school age, the effects of dopamine pathway genes variants with teachers and parent ratings the children’s symptoms assessed. Given the importance the scientific methodology for children with ADHD, Dr. Froehlich said it is medication drug effects at school and at home. Children in the study not already under stimulant medications for their ADHD.
Children, what is missing as the DAT 10 – repeat variant known showed greater improvement after taking the people that the 10 – repeat compared with methylphenidate. Children without DRD4 gene 4 – repeat variant showed less symptomatic improvement with methylphenidate compared with the 4 – repeat carriers. ‘repeat’ ‘repeat’is a short nucleotide coding sequences in a gene, which is repeated. Froehlich and her colleagues show in their study, although results are promising, additional studies in larger patient samples are confirm the confirm the current study results and their clinical relevance. Read the rest of this entry »